Phytochemicals modulate key cellular signaling pathways and have proven anticancer effects. Salts and esters of gallic acid are termed "gallates". 1, pp. It has characteristics of the strong antioxidant and free radical scavenging activities, and can protect biological cells, tissues, and organs from damages caused by oxidative stress. Gallic acid and gallate esters are widely used as dietary supplements or additives with clinical significances. Author information: (1)Department of Chemistry, University of Sheffield, Sheffield S3 7HF. Eur. It has characteristics of Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. In this review, studies of the effects of gallic acid, its esters, and gallic acid catechin derivatives on Phase I and Phase II enzymes are examined. (2020). A patent was granted (Weetal, 1985b) for the synthesis of propyl gallate using tannase immobilized on porous silica. Reviewers in the relevant research area assess submitted manuscripts for originality, validity and significance to help editors to determine whether the manuscript should be published in the journal. There are several reports for the pharmacological activities of gallic acid and its derivatives. The concentrations of vanillic acid and gallic acid needed for 50% inhibition (I 50 values) of the seedling growth of the cress and Italian ryegrass were 0.04-15.4 and 0.45-6.6 mM, respectively. In addition to prescription drugs, nutraceuticals/medicinal foods are progressively included as adjunct of cardiovascular maladies, cancer, hepatitis C, inflammation, HCV infection and neurological disorders, even though most of them have been exclusively studied in vitro. Introduction. Its supplements are available as capsules, ointments and liquid extracts, and have been used traditionally to treat a variety of ailments. Exploring the multifaceted neuroprotective actions of gallic acid: a review. See customer reviews, validations & product citations. Abstract. Tea infusion contains caffeine along with different acids such as gallic acid, oxalic acid, and tannic acid, which can form stable co‐crystals. Thank you for your interest in spreading the word about The BMJ. Gallic acid (GA), a polyphenolic compound, has been reported to prevent various diseases. Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and ... Quality confirmed by NMR & HPLC. A Role of Gallic Acid in Oxidative Damage Diseases: A Comprehensive Review Jiayu Gao1, Jiangxia Hu1, Dongyi Hu1, and Xiao Yang2 Abstract Gallic acid is a trihydroxybenzoic acid of plant metabolites widely spread throughout the plant kingdom. Gallic acid (3,4,5 trihydroxybenzoic acid) is a secondary metabolite present in most plants. Gallic acid was added to the fibrils in PB such that the final concentration of gallic acid was 0, 0.1, 0.5, or 1.0 m m. The ascorbic acid stock solution was made by dissolving ascorbic acid powder in PB. The gallic acid stock solution was prepared by dissolving gallic acid powder in 20 m m PB, pH 7.4. GALLICUM ACIDUM AC- gallic acid monohydrate pellet Under Review - Editing is pending for RxNorm. Gallic acid is also used in the enzymatic synthesis of propyl gallate, which is mainly used an an antioxidant in fats and oils, as well as in beverages (Weetal, 1985a). It is a white solid, although samples are typically brown owing to partial oxidation. PG is the n-propyl ester of gallic acid. Gallic acid is a trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. This metabolite is known to exhibit a range of bioactivities including antioxidant, antimicrobial, anti-inflammatory, and anticancer. ... Peer-review. Thus, it is esterified with propionic acid to increase lipid solubility. In nature, these compounds are widely distributed in plants and fruits, and thus they are being used as food stuffs, preservatives, etc. Gallic acid (GA), one of the most abundant phenolic acids in the plant kingdom, has been shown potential chemotherapeutic efficacy against microbial and cancer. Because of the presence of the three hydroxyls, gallic acid esters make very effective antioxidants. However, the effects of GA on KSHV replication and KSHV‐induced tumorigenesis have not yet been reported. Gallic acid is one such diet-derived phenolic substance being surveyed. Plant polyphenols (vegetable tannins): gallic acid metabolism. Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid. PMID: 15206456 [Indexed for MEDLINE] Publication Types: Review; MeSH terms. 2020 “Gallic acid” Market research report is an ancient evaluation and in-intensity observe on the present-day and future market of the Gallic acid. Gallic acid and its derivatives have a large number of applications in various fields of science. Gallic acid (GA), a natural component of many plants, is used as an antioxidant agent. J. Med. Gallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. Review of literature reveals hepatoprotective potential of gallic acid in alleviating paracetamol-induced liver damage in mice, hepatic ischemia reperfusion injury in rats, CCl 4-induced acute However, the molecular mechanism underlying this inhibitory effect was poorly understood. Haslam E(1), Cai Y. Chem. Numerous studies have indicated that the alkyl esters are more effective against tumor cell lines than gallic acid, and that this activity is related to their hydrophobic moiety. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer.It is a conjugate acid of a gallate. They have also been im … Gallic acid or 3, 4, 5‐trihydroxybenzoic acid (CAS No 149‐91‐7) is one of the most abundant phenolic acids in the plant kingdom (Al Zahrani et al., 2020). 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